4.5 Article

Diversity analysis of gut microbiota between healthy controls and those with atopic dermatitis in a Chinese population

期刊

JOURNAL OF DERMATOLOGY
卷 48, 期 2, 页码 158-167

出版社

WILEY
DOI: 10.1111/1346-8138.15530

关键词

16S rRNA; atopic dermatitis; dominant bacteria; gut microbiota; species composition

资金

  1. National Natural Science Foundation of China [81774307]
  2. Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases [2018B030322012, MB2020KF04]

向作者/读者索取更多资源

The gut microbiota is increasingly recognized to be involved in atopic dermatitis. Differences in composition were observed between healthy controls and AD patients, suggesting potential for microbiota as diagnostic markers or targets for intervention in AD.
An increasing body of evidence suggests that gut microbiota is involved in atopic dermatitis (AD). We aimed to use high-throughput sequencing to characterize the differences in the composition of the gut microbiota between healthy controls and patients with AD. Fecal samples from 93 volunteers were analyzed using 16S rRNA sequencing, including 44 patients with AD and 49 healthy control subjects, aged 6-22 years. Our data show that the operational taxonomic unit composition in patients with AD had greater component similarity than the healthy controls. Patients with AD had a lower alpha diversity than healthy control subjects. The relative abundance of Porphyromonadaceae, Blautia, Parabacteroides, Bacteroides ovatus, Bacteroides uniformisandPrevotella stercoreawas significantly higher (P < 0.05) in patients with AD than healthy control subjects.ClostridiumandP. stercoreawere higher (P < 0.05) in healthy control subjects compared with patients with AD. The results of linear discriminant analysis effect size show thatBacteroidaceaeandPorphyromonadaceaecan act as possible biomarkers associated with diagnosis of AD. However, this needs further experimental verification. Taken together, these results demonstrate the changes in microbiota composition in AD compared with a healthy control group, opening the way to future diagnosis or intervention studies.

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