Selenium Tethered Mesoporous Silica Nanocomposite Enhances Drug Delivering Efficiency to Target Breast Cancer

The development of multifunctional nanocomposite can greatly improve therapeutic effects to impair tumor proliferation. In the present study, we developed a new class of dual-drug delivering system, the Selenium Mesoporous Silica (SMS) nanocomposites to achieve molecular based tumor-targeting. A series of experiments have been performed to tether Mesoporous Silica nanoparticle (MSN) with chitosan-selenium complex using cysteine amino acid. The Chemical and biological assays authenticated that a perfect chemistry works between the formulated SMS nanocomposites and selected drugs, namely, Metformin (MT) and Cisplatinn (Cis). As a sequential reaction, the MT-MSN-CS-Se-Cis nanocomposites allowed the cRGD peptide to attach with MSN. Furthermore, the sulfur groups of MT-MSN-Cys make a conjugation with Se-Cis-CS material, on which cRGD peptide was grafted as a target moiety. This multifunctional SMS nanocomposite enhances specific cellular uptake of drugs, controlled release and higher inhibitory effects against MDA-MB-231 cells. Further studies demonstrated that the formulated nanocomposites significantly induce apoptosis through DNA damage and ROS overproduction that accounts for critical antitumor activity. Additionally, animal studies provide significantly enhanced the anti-tumor efficacy of formulated nanocomposites on tumor-bearing mice. Hence, the formulated nanocomposite is an effective multifunctional drug delivery podium which might have elicited the molecular targeted chemotherapeutic efficacy against cancer.

Automated summary

The study developed Selenium Mesoporous Silica (SMS) nanocomposites as a dual-drug delivering system with strong anti-tumor effects for molecular targeting. Through a series of experiments, perfect chemistry between the formulated nanocomposites and selected drugs was verified, enhancing specific cellular uptake and inhibitory effects, promoting apoptosis of tumor cells.