期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 130, 期 10, 页码 5052-5062出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI137553
关键词
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资金
- Research Grant Council-Theme-Based Research Fund [T12-704/16-R]
- State Key Laboratory of Liver Research
- Croucher Innovation Award
- University of Hong Kong Outstanding Young Researcher Award
The liver has strong innate immunity to counteract pathogens from the gastrointestinal tract. During the development of liver cancer, which is typically driven by chronic inflammation, the composition and biological roles of the innate immune cells are extensively altered. Hypoxia is a common finding in all stages of liver cancer development. Hypoxia drives the stabilization of hypoxia-inducible factors (HIFs), which act as central regulators to dampen the innate immunity of liver cancer. HIF signaling in innate immune cells and liver cancer cells together favors the recruitment and maintenance of pro-tumorigenic immune cells and the inhibition of anti-tumorigenic immune cells, promoting immune evasion. HIFs represent attractive therapeutic targets to inhibit the formation of an immunosuppressive microenvironment and growth of liver cancer.
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