期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 106, 期 3, 页码 E1488-E1493出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgaa691
关键词
time-restricted feeding; circadian rhythm; melatonin; intermittent fasting; circadian clock
资金
- US National Institutes of Health [EY016807, DK118278, DK115214]
- Department of Defense [W81XWH1810645]
- Department of Homeland Security [EMW-2016-FP-00788]
- Robert Wood Johnson Foundation [76014]
- Paul F. Glenn Center for the Biology of Aging
- U.S. Department of Defense (DOD) [W81XWH1810645] Funding Source: U.S. Department of Defense (DOD)
Metabolic homeostasis is regulated by endocrine factors, signaling cascades, and metabolic pathways, which are also modulated by circadian rhythm. Disruption of circadian rhythm can increase the risk for metabolic diseases. Understanding factors affecting circadian rhythm allows for implementing new interventions to prevent and manage metabolic disorders.
Metabolic homeostasis is achieved by endocrine factors, signaling cascades, and metabolic pathways that sense and respond to metabolic demands in different organs. However, the recent discovery that almost every component of this regulatory system is also modulated by circadian rhythm highlights novel etiology and prognosis of metabolic diseases. First, chronic circadian rhythm disruption, as in shiftwork or shiftwork-like lifestyle, can increase the risk for metabolic diseases. Second, by understanding factors that affect circadian rhythm, we can implement new behavioral or pharmacological interventions for the prevention and management of metabolic disorders. One of these novel circadian-based interventions is time-restricted eating (TRE) in which all daily caloric intake is restricted to a consistent window of 8 to 12 hours. In preclinical animal models, TRE can prevent or reverse many metabolic diseases. Circadian research has also catalyzed attempts to optimally time the dosing of existing drugs to treat metabolic diseases or develop new drugs that target the circadian clock to treat metabolic disorders.
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