期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1627, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.chroma.2020.461387
关键词
Magnetic covalent organic framework; Magnetic solid-phase extraction; Adsorbent; Organophosphorus pesticides; Milk
资金
- National Key Research and Development Program of China [2017YFC1601600]
- Key Research and Development Program of Zhejiang Province [2020C02023]
- State Key Laboratory for Quality and Safety of Agro-products [2010DS700124-KF1905, 2010DS700124-ZZ2009]
- special Fund for Public Projects of Zhejiang Province [LGN19B070001]
A simple and efficient magnetic solid-phase extraction (MSPE) method was established with magnetic covalent organic framework (COF) as adsorbent to enrich organophosphorus pesticides from fatty milk samples, followed by the sensitive determination via LC-MS/MS. The key parameters influencing the MSPE efficiency were comprehensively investigated to afford an optimized procedure. All the target analytes could be captured directly by magnetic COF from milk without protein precipitation, making the pretreatment rapid and convenient. Systematic method validation demonstrated its satisfactory linearity, recoveries (80.0-105 %), and precision (RSDs <12.3 %). The method limits of quantification were 0.2-0.5 mu g L-1. A comparison experiment to the reported solid-phase extraction fully verified the present MSPE more rapid, accurate, and environment-friendly. Furthermore, FT-IR and XPS analysis were performed to reveal the adsorption mechanisms of magnetic COF to organophosphorus pesticides, which could offer guidance on the rational design of COF adsorbent for various target analytes. (c) 2020 Elsevier B.V. All rights reserved.
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