期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 41, 期 6, 页码 1291-1300出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X20958755
关键词
Dopamine transporter; [F-18]FE-PE2I; Parkinson's disease; reliability; specific binding ratio
资金
- Swedish Foundation for Strategic Research
- Swedish Science Council
- Ahlen Foundation
- H. Lundbeck A/S
- German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) [BR 6121/1-1]
Quantification of dopamine transporter availability using [F-18]FE-PE2I PET can be a potential marker for Parkinson's disease progression. Early peak equilibrium acquisition provides better effectiveness and reliability in distinguishing PD patients from controls.
Quantification of dopamine transporter (DAT) availability with [F-18]FE-PE2I PET enables the detection of presynaptic dopamine deficiency and provides a potential progression marker for Parkinson`s disease (PD). Simplified quantification is feasible, but the time window of short acquisition protocols may have a substantial impact on the reliability of striatal binding estimates. Dynamic [F-18]FE-PE2I PET data of cross-sectional (33 PD patients, 24 controls), test-retest (9 patients), and longitudinal (12 patients) cohorts were used to assess the variability and reliability of specific binding ratios (SBR) measured during early peak and late pseudo-equilibrium. Receiver operating characteristics area under the curve (PD vs. controls) was high for early (0.996) and late (0.991) SBR. Early SBR provided more favourable effect size, absolute variability, and standard error of measurement than late SBR (caudate: 1.29 vs. 1.23; 6.9% vs. 9.8%; 0.09 vs. 0.20; putamen: 1.75 vs. 1.67; 7.7% vs. 14.0%; 0.08 vs. 0.17). The annual percentage change was comparable for both time windows (-7.2%-8.5%), but decline was significant only for early SBR. Whereas early and late [F-18]FE-PE2I PET acquisitions have similar discriminative power to separate PD patients and controls, the early peak equilibrium acquisition can be recommended if [F-18]FE-PE2I is used to measure longitudinal changes of DAT availability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据