Sorting nexins: A novel promising therapy target for cancerous/neoplastic diseases

Sorting nexins (SNXs) are a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins containing the PX domain proteins. The function of SNX proteins in regulating intracellular protein trafficking consists of endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX proteins are demonstrated to be involved in several cancerous/neoplastic diseases. Here, we review the accumulated evidence of the molecular structure and biological function of SNX proteins and discuss the regulatory role of SNX proteins in distinct cancerous/neoplastic diseases. SNX family proteins may be a valuable potential biomarker and therapeutic strategy for diagnostics and treatment of cancerous/neoplastic diseases.

Automated summary

Sorting nexins (SNXs) are a group of diverse cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play a crucial role in regulating intracellular protein trafficking. Dysfunctions of SNX proteins have been linked to various cancerous/neoplastic diseases, making them potential biomarkers and therapeutic targets for cancer diagnostics and treatment.