相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Therapeutic targeting of RAS: New hope for drugging the undruggable
Imran Khan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)
mTOR at the nexus of nutrition, growth, ageing and disease
Grace Y. Liu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Growth Factor-Dependent and -Independent Activation of mTORC2
Jonas R. Knudsen et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)
The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism
Gerta Hoxhaj et al.
NATURE REVIEWS CANCER (2020)
Progress in targeting RAS with small molecule drugs
Frank McCormick
BIOCHEMICAL JOURNAL (2019)
Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt
Catherine E. Gleason et al.
JOURNAL OF CELL SCIENCE (2019)
Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2
Maria Nieves Martinez Marshall et al.
MOLECULAR BIOLOGY OF THE CELL (2019)
Phosphorylated Rho-GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras-GTP to regulate cell migration
Hiroshi Senoo et al.
NATURE CELL BIOLOGY (2019)
A Comparative Analysis of Individual RAS Mutations in Cancer Biology
Carmen Munoz-Maldonado et al.
FRONTIERS IN ONCOLOGY (2019)
Does Ras Activate Raf and PI3K Allosterically?
Ruth Nussinov et al.
FRONTIERS IN ONCOLOGY (2019)
Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling
Mehraj-U-Din Lone et al.
BMC CANCER (2019)
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2
Joanna R. Kovalski et al.
MOLECULAR CELL (2019)
Integrated actions of mTOR complexes 1 and 2 for growth and development of Dictyostelium
Pundrik Jaiswal et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2019)
Ras and the Plasma Membrane: A Complicated Relationship
Yong Zhou et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)
Who does TORC2 talk to?
Jianling Xie et al.
BIOCHEMICAL JOURNAL (2018)
Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex
Anastasios Gkountakos et al.
CARCINOGENESIS (2018)
Cryo-EM structure of human mTOR complex 2
Xizi Chen et al.
CELL RESEARCH (2018)
Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms
Saeideh Nakhaei-Rad et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)
The role of mTOR-mediated signaling in the regulation of cellular migration
Ailsa K. Holroyd et al.
IMMUNOLOGY LETTERS (2018)
mTORC1 and mTORC2 in cancer and the tumor microenvironment
L. C. Kim et al.
ONCOGENE (2017)
Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid
Deepak Menon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Localization of mTORC2 activity inside cells
Michael Ebner et al.
JOURNAL OF CELL BIOLOGY (2017)
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
Haijuan Yang et al.
NATURE (2017)
Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2
Saori Mukaida et al.
PHARMACOLOGICAL RESEARCH (2017)
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
Manikandan Karuppasamy et al.
NATURE COMMUNICATIONS (2017)
Modeling of RAS complexes supports roles in cancer for less studied partners
H. Billur Engin et al.
BMC BIOPHYSICS (2017)
Association of mSin1 with mTORC2 Ras and Akt reveals a crucial domain on mSin1 involved in Akt phosphorylation
Chien-An Yao et al.
ONCOTARGET (2017)
Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit
Hisashi Tatebe et al.
ELIFE (2017)
Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling
Thomas C. Buckles et al.
BIOPHYSICAL JOURNAL (2017)
The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae
Francoise M. Roelants et al.
BIOMOLECULES (2017)
The PI3K Pathway in Human Disease
David A. Fruman et al.
CELL (2017)
RAS Proteins and Their Regulators in Human Disease
Dhirendra K. Simanshu et al.
CELL (2017)
mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR
Yancun Yin et al.
CELL RESEARCH (2016)
Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin
Zhipeng Zou et al.
CURRENT CANCER DRUG TARGETS (2016)
Mammalian target of rapamycin (mTOR) complex 2 regulates filamin A-dependent focal adhesion dynamics and cell migration
Tatsuhiro Sato et al.
GENES TO CELLS (2016)
RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
Esther Castellano et al.
NATURE COMMUNICATIONS (2016)
The small GTPases Ras and Rap1 bind to and control TORC2 activity
Ankita Khanna et al.
SCIENTIFIC REPORTS (2016)
Significance of filamin A in mTORC2 function in glioblastoma
Naphat Chantaravisoot et al.
MOLECULAR CANCER (2015)
Ras, Rac1, and phosphatidylinositol-3-kinase (PI3K) signaling in nitric oxide induced endothelial cell migration
Roberta Eller-Borges et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2015)
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
Pengda Liu et al.
CANCER DISCOVERY (2015)
Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
Long Chen et al.
ONCOTARGET (2015)
A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
Guang Yang et al.
CELL REPORTS (2015)
mTOR Regulate EMT Through RhoA and Rac1 Pathway in Prostate Cancer
XianGuo Chen et al.
MOLECULAR CARCINOGENESIS (2015)
Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis
Maikel A. Farhan et al.
PLOS ONE (2015)
Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle
Masaaki Sato et al.
DIABETES (2014)
Classes of phosphoinositide 3-kinases at a glance
Steve Jean et al.
JOURNAL OF CELL SCIENCE (2014)
Rictor Negatively Regulates High-Affinity Receptors for IgE-Induced Mast Cell Degranulation
Daniel Smrz et al.
JOURNAL OF IMMUNOLOGY (2014)
Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton
Yuan He et al.
MOLECULAR BIOLOGY OF THE CELL (2013)
The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts
Jervis Vermal Thevathasan et al.
MOLECULAR BIOLOGY OF THE CELL (2013)
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Jonathan M. Ostrem et al.
NATURE (2013)
Sinl phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
Pengda Liu et al.
NATURE CELL BIOLOGY (2013)
Phosphatidic acid and lipid-sensing by mTOR
David A. Foster
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)
Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis
Shile Huang et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2012)
TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing
Daniel Rosel et al.
JOURNAL OF CELL SCIENCE (2012)
Cooperative Activation of PI3K by Ras and Rho Family Small GTPases
Hee Won Yang et al.
MOLECULAR CELL (2012)
mTORC2 targets AGC kinases through Sin1-dependent recruitment
Angus J. M. Cameron et al.
BIOCHEMICAL JOURNAL (2011)
mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
Pat Gulhati et al.
CANCER RESEARCH (2011)
Activation of mTORC2 by Association with the Ribosome
Vittoria Zinzalla et al.
CELL (2011)
mTORC1- and mTORC2-interacting Proteins Keep Their Multifunctional Partners Focused
Ismael Bracho-Valdes et al.
IUBMB LIFE (2011)
Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate
Xiaoqing Gan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
TOR kinase complexes and cell migration
Lunhua Liu et al.
JOURNAL OF CELL BIOLOGY (2011)
Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
Abdelhafid Saci et al.
MOLECULAR CELL (2011)
RAS oncogenes: weaving a tumorigenic web
Yuliya Pylayeva-Gupta et al.
NATURE REVIEWS CANCER (2011)
mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion
Lunhua Liu et al.
DEVELOPMENTAL CELL (2010)
A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration
Pascale G. Charest et al.
DEVELOPMENTAL CELL (2010)
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
Won Jun Oh et al.
EMBO JOURNAL (2010)
Phosphoinositide-dependent Protein Kinase (PDK) Activity Regulates Phosphatidylinositol 3,4,5-Trisphosphate-dependent and -independent Protein Kinase B Activation and Chemotaxis
Yoichiro Kamimura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis
Huaqing Cai et al.
JOURNAL OF CELL BIOLOGY (2010)
The emerging mechanisms of isoform-specific PI3K signalling
Bart Vanhaesebroeck et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Self-organization of the phosphatidylinositol lipids signaling system for random cell migration
Yoshiyuki Arai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
Dominico Vigil et al.
NATURE REVIEWS CANCER (2010)
Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor
Joseph Avruch et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
The Hypervariable Region of K-Ras4B Is Responsible for Its Specific Interactions with Calmodulin
Sherwin J. Abraham et al.
BIOCHEMISTRY (2009)
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson et al.
CELL (2009)
TORC2 Plasma Membrane Localization Is Essential for Cell Viability and Restricted to a Distinct Domain
Doris Berchtold et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
3′-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis
J. S. Gruver et al.
BIOPHYSICAL JOURNAL (2008)
Spatiotemporal Regulation of Ras Activity Provides Directional Sensing
Sheng Zhang et al.
CURRENT BIOLOGY (2008)
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis
Yoichiro Kamimura et al.
CURRENT BIOLOGY (2008)
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
Tsuneo Ikenoue et al.
EMBO JOURNAL (2008)
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Valeria Facchinetti et al.
EMBO JOURNAL (2008)
TOR1 and TOR2 Have Distinct Locations in Live Cells
Thomas W. Sturgill et al.
EUKARYOTIC CELL (2008)
The regulation of cell motility and chemotaxis by phospholipid signaling
Verena Kolsch et al.
JOURNAL OF CELL SCIENCE (2008)
PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients
Leonard Bosgraaf et al.
JOURNAL OF CELL SCIENCE (2008)
Syndecan-4 Regulates Subcellular Localization of mTOR Complex2 and Akt Activation in a PKCα-Dependent Manner in Endothelial Cells
Chohreh Partovian et al.
MOLECULAR CELL (2008)
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility
Atsuo T. Sasaki et al.
JOURNAL OF CELL BIOLOGY (2007)
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling
Wayne A. Schroder et al.
CELLULAR SIGNALLING (2007)
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium
Kosuke Takeda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Big roles for small GTPases in the control of directed cell movement
Pascale G. Charest et al.
BIOCHEMICAL JOURNAL (2007)
Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae
Thomas Strahl et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)
Gβγs and the Ras binding domain of p110γ are both important regulators of PI(3)Kγ signalling in neutrophils
Sabine Suire et al.
NATURE CELL BIOLOGY (2006)
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
Qian Yang et al.
GENES & DEVELOPMENT (2006)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum
Parvin Bolourani et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
Maria A. Frias et al.
CURRENT BIOLOGY (2006)
Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase
FI Comer et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium
S Lee et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Recognizing and defining true Ras binding domains 1:: Biochemical analysis
S Wohlgemuth et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis
SA Myers et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Rheb binds and regulates the mTOR kinase
X Long et al.
CURRENT BIOLOGY (2005)
Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis
C Janetopoulos et al.
DEVELOPMENTAL CELL (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis
FI Corner et al.
CURRENT BIOLOGY (2005)
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
AT Sasaki et al.
JOURNAL OF CELL BIOLOGY (2004)
Sensitization of Dictyostelium chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patches
M Postma et al.
JOURNAL OF CELL SCIENCE (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity
C Thornton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae
KP Wedaman et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Sphingosine-1-phosphate induces Gαi-coupled, PI3K/ras-dependent smooth muscle cell migration
W Tanski et al.
JOURNAL OF SURGICAL RESEARCH (2002)
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
F Wang et al.
NATURE CELL BIOLOGY (2002)
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
S Funamoto et al.
CELL (2002)
RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation
CJ Lim et al.
EMBO JOURNAL (2001)
Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium
S Funamoto et al.
JOURNAL OF CELL BIOLOGY (2001)
HEAT repeats mediate plasma membrane localization of Tor2p in yeast
J Kunz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)