期刊
JOURNAL OF CELL SCIENCE
卷 133, 期 18, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.239889
关键词
Basement membrane; Endothelial cells; Structured surface; Surface topography; Vascular disease; Vascular tissue engineering
类别
资金
- AXA Research Fund
- Fondation Lefoulon-Delalande
The basement membrane (BM) is a thin specialized extracellular matrix that functions as a cellular anchorage site, a physical barrier and a signaling hub. While the literature on the biochemical composition and biological activity of the BM is extensive, the central importance of the physical properties of the BM, most notably its mechanical stiffness and topographical features, in regulating cellular function has only recently been recognized. In this Review, we focus on the biophysical attributes of the BM and their influence on cellular behavior. After a brief overview of the biochemical composition, assembly and function of the BM, we describe the mechanical properties and topographical structure of various BMs. We then focus specifically on the vascular BM as a nano- and microscale structured surface and review how its architecture can modulate endothelial cell structure and function. Finally, we discuss the pathological ramifications of the biophysical properties of the vascular BM and highlight the potential of mimicking BM topography to improve the design of implantable endovascular devices and advance the burgeoning field of vascular tissue engineering.
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