期刊
JOURNAL OF CELL BIOLOGY
卷 219, 期 12, 页码 -出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202005179
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资金
- National Institutes of Health, Office of Research Infrastructure Programs [P40 OD010440]
- National Institute of General Medical Sciences [1R01GM079421, 1R35GM124889]
- U.S. Department of Agriculture/National Institute of Food and Agriculture Hatch project [1009162]
- NIFA [1009162, 913148] Funding Source: Federal RePORTER
Anaphase chromosome movement is thought to be mediated by pulling forces generated by end-on attachment of microtubules to the outer face of kinetochores. However, it has been suggested that during C. elegans female meiosis, anaphase is mediated by a kinetochore-independent pushing mechanism with microtubules only attached to the inner face of segregating chromosomes. We found that the kinetochore proteins KNL-1 and KNL-3 are required for preanaphase chromosome stretching, suggesting a role in pulling forces. In the absence of KNL-1,3, pairs of homologous chromosomes did not separate and did not move toward a spindle pole. Instead, each homolog pair moved together with the same spindle pole during anaphase B spindle elongation. Two masses of chromatin thus ended up at opposite spindle poles, giving the appearance of successful anaphase.
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