相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Recurring genomic structural variation leads to clonal instability and loss of productivity
Arpan A. Bandyopadhyay et al.
BIOTECHNOLOGY AND BIOENGINEERING (2019)
Mitigating Clonal Variation in Recombinant Mammalian Cell Lines
Jae Seong Lee et al.
TRENDS IN BIOTECHNOLOGY (2019)
Considering clonality: A regulatory perspective on the importance of the clonal derivation of mammalian cell banks in biopharmaceutical development
Joel T. Welch et al.
BIOLOGICALS (2019)
Changes in Chromosome Counts and Patterns in CHO Cell Lines upon Generation of Recombinant Cell Lines and Subcloning
Sabine Vcelar et al.
BIOTECHNOLOGY JOURNAL (2018)
Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line
Tharmala Tharmalingam et al.
BIOTECHNOLOGY PROGRESS (2018)
Changes in Chromosome Counts and Patterns in CHO Cell Lines upon Generation of Recombinant Cell Lines and Subcloning
Sabine Vcelar et al.
BIOTECHNOLOGY JOURNAL (2018)
Analytical assessment of clonal derivation of eukaryotic/CHO cell populations
Christel Aebischer-Gumy et al.
JOURNAL OF BIOTECHNOLOGY (2018)
Revealing Key Determinants of Clonal Variation in Transgene Expression in Recombinant CHO Cells Using Targeted Genome Editing
Jae Seong Lee et al.
ACS SYNTHETIC BIOLOGY (2018)
Probing the importance of clonality: Single cell subcloning of clonally derived CHO cell lines yields widely diverse clones differing in growth, productivity, and product quality
Peggy Ko et al.
BIOTECHNOLOGY PROGRESS (2018)
Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Thomas Beuchert Kallehauge et al.
SCIENTIFIC REPORTS (2017)
Engineering Structurally Interacting RNA (sxRNA)
Francis Doyle et al.
SCIENTIFIC REPORTS (2017)
Cloning of CHO Cells, Productivity and Genetic Stability-A Discussion
Florian M. Wurm et al.
PROCESSES (2017)
Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest
Xuan Droz et al.
BIOTECHNOLOGY AND BIOENGINEERING (2017)
Industry view on the relative importance of clonality of biopharmaceutical-producing cell lines
Christopher Frye et al.
BIOLOGICALS (2016)
Surface Display Vectors for Selective Detection and Isolation of High Level Antibody Producing Cells
Sabine Lang et al.
BIOTECHNOLOGY AND BIOENGINEERING (2016)
The art of CHO cell engineering: A comprehensive retrospect and future perspectives
Simon Fischer et al.
BIOTECHNOLOGY ADVANCES (2015)
Recombinase-Mediated Cassette Exchange (RMCE) for Monoclonal Antibody Expression in the Commercially Relevant CHOK1SV Cell Line
Lin Zhang et al.
BIOTECHNOLOGY PROGRESS (2015)
EBV BART MicroRNAs Target Multiple Pro-apoptotic Cellular Genes to Promote Epithelial Cell Survival
Dong Kang et al.
PLOS PATHOGENS (2015)
Comparative characterization of mAb producing hapten-specific hybridoma cells by flow cytometric analysis and ELISA
Maren Kuhne et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2014)
A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells
Dong-Ki Choi et al.
MABS (2014)
Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform
Atefeh Ghorbaniaghdam et al.
PLOS ONE (2014)
CHO cells in biotechnology for production of recombinant proteins: current state and further potential
Jee Yon Kim et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2012)
CHO-K1 host cells adapted to growth in glutamine-free medium by FACS-assisted evolution
Juan A. Hernandez Bort et al.
BIOTECHNOLOGY JOURNAL (2010)
Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system
Hong Zhou et al.
JOURNAL OF BIOTECHNOLOGY (2010)
Cell culture processes for monoclonal antibody production
Feng Li et al.
MABS (2010)
A systematic study of the function of the human β-globin introns on the expression of the human coagulation factor IX in cultured Chinese hamster ovary cells
Aliakbar Haddad-Mashadrizeh et al.
JOURNAL OF GENE MEDICINE (2009)
Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells
Warren Pilbrough et al.
PLOS ONE (2009)
Epstein-Barr virus BART microRNAs are produced from a large intron prior to splicing
Rachel Hood Edwards et al.
JOURNAL OF VIROLOGY (2008)
Characterisation of recombinant CHO cell lines by investigation of protein productivities and genetic parameters
Christine Lattenmayer et al.
JOURNAL OF BIOTECHNOLOGY (2007)
ACSD labelling and magnetic cell separation: a rapid method of separating antibody secreting cells from non-secreting cells
S Carroll et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2005)
Illegitimate DNA integration in mammalian cells
H Würtele et al.
GENE THERAPY (2003)