期刊
JOURNAL OF BIOPHOTONICS
卷 14, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202000287
关键词
epilepsy; omega-3; photobiomodulation; stroke
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [302583/2017-3]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES) [001]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2016/10286-7]
Studies have shown that transcranial photobiomodulation (PBM) treatment reduced seizure duration and spike numbers in post-stroke epilepsy, suggesting it as a potential therapeutic approach.
Epilepsy is a yet under-recognized consequence after a stroke and nearly 30% of cases are pharmacoresistant. There is an unmet need for therapeutic interventions during epileptogenesis for better long-term disease outcomes. Transcranial photobiomodulation (PBM) and omega-3 (omega-3) dietary supplementation are two approaches that have been shown promising neuroprotective effects after brain injuries. Here, we studied the PBM treatment or omega-3 diet during epileptogenesis in long-term recurrent spontaneous abnormal electrical discharges after stroke. Wistar rats received repetitive 780 nm-laser in the scalp or oral diet with omega-3 for 2-months after photothrombotic stroke. EEG recordings were performed 60 days after treatment end. PBM but not omega-3 reduced both electrographic seizure duration and spikes number in the ipsilateral and contralateral cortices and ventral posteromedial thalamic nucleus. Conclusively, PBM reduced epileptiform discharges in stroke-induced epilepsy. Our results suggest the PBM as a therapeutic approach for stroke-induced epileptogenesis to minimize long-term disease outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据