A new prenylated coumarin diglycoside with insulin-release promoting activity fromClausena dunniana

A new prenylated coumarin diglycoside, 6-prenylcoumarin-7-O-beta-D-apiofuranosyl-(1 -> 6)-beta-D-glucopyranoside (1) and five known flavonoid glycosides (2-6) were isolated from the leaves and stems ofClausena dunniana. The structures of these isolates were elucidated based on comprehensive MS, UV, IR, and NMR spectroscopic data analysis and comparison with the data reported in literature. Compounds2-6are obtained from the title plant for the first time. All these isolates were evaluated for their insulin-release promoting effects, and compounds1,2, and4exhibited significant activities (2.0 to 3.3-fold higher in comparison with the control,p < 0.01) at 40 mu M.

Automated summary

A new prenylated coumarin diglycoside and five known flavonoid glycosides were isolated from the leaves and stems of Clausena dunniana. These compounds were evaluated for their insulin-release promoting effects, with compounds 1, 2, and 4 exhibiting significant activities at 40 µM.