Strepyrazinone, a tricyclic diketopiperazine derivative with cytotoxicity from a marine-derived actinobacterium

Strepyrazinone (1), a tricyclic diketopiperazine derivative with a carbon skeleton unprecedented in natural products, was isolated from the marine-derivedStreptomycessp. B223. Its structure was elucidated by spectroscopic analyses and electronic circular dichroism calculation. Compound1showed cytotoxic activity against HCT-116 cancer cell lines with an IC(50)value of 0.34 mu M.

Automated summary

Strepyrazinone (1), a novel tricyclic diketopiperazine derivative with an unprecedented carbon skeleton in natural products, was isolated from marine-derived Streptomyces sp. B223. Its cytotoxic activity against HCT-116 cancer cell lines with an IC(50) value of 0.34 μM was demonstrated.