期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 138, 期 8, 页码 -出版社
WILEY
DOI: 10.1002/app.49888
关键词
biodegradable; biomaterials; biomedical applications; biomimetic; biopolymers and renewable polymers
资金
- Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai [PWZxq2017-11]
- National Natural Science Foundation of China [81971753]
- Outstanding Clinical Discipline Project of Shanghai Pudong [PWYgy2018-09]
- Program for Outstanding Leader of Shanghai [046]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (CN) [ZK2019C01]
The review discusses the development of bioprinting technology for bone defect regeneration and focuses on the priority of different types of bioprinting technologies for the preparation of cell/growth factor-laden matrixes, as well as key aspects such as bio-ink compositions and effective parameters.
Although many efforts have been made to regenerate the bone lesions, existing challenges can be mitigated through the development of tissue engineering scaffolds. However, the weak control on the microstructure of constructs, limitation in preparation of patient-specific and multilayered scaffolds, restriction in the fabrication of cell-laden matrixes, and challenges in preserving the drug/growth factors' efficacy in conventional methods have led to the development of bioprinting technology for regeneration of bone defects. So in this review, conventional 3D printers are classified, then the priority of the different types of bioprinting technologies for the preparation of the cell/growth factor-laden matrixes are focused. Besides, the bio-ink compositions, including polymeric/hybrid hydrogels and cell-based bio-inks are classified according to fundamental and recent studies. Herein, different effective parameters, such as viscosity, rheological properties, cross-linking methods, biodegradation biocompatibility, are considered. Finally, different types of cells and growth factors that can encapsulate in the bio-inks to promote bone repair are discussed, and both in vitro and in vivo achievement are considered. This review provides current and future perspectives of cell-laden bioprinting technologies. The restrictions and challenges are identified, and proper strategies for the development of cell-laden matrixes and high-performance printable bio-inks are proposed.
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