期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 78, 期 2, 页码 827-835出版社
IOS PRESS
DOI: 10.3233/JAD-200392
关键词
AHEI-2010; cognition; DASH; dementia; dietary pattern; HEI-2015; Mediterranean diet
资金
- National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute [T32 HL007024]
- National Institute of Diabetes and Digestive and Kidney Diseases [K01 DK107782]
- National Heart, Lung, and Blood Institute [R21 HL143089, HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I]
- NIH (NHLBI) [U012 U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917]
- NIH (NINDS) [U012 U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917]
- NIH (NIA) [U012 U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917]
- NIH (NIDCD) [U012 U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917]
- NHLBI [R01-HL70825]
- [K24 AG052573]
Background: Previous studies have suggested that adherence to healthy dietary patterns during late life may be associated with improved cognition. However, few studies have examined the association between healthy dietary patterns during midlife and incident dementia. Objective: Our study aimed to determine the association between adherence to healthy dietary patterns at midlife and incident dementia. Methods: We included 13,630 adults from the Atherosclerosis Risk in Communities (ARIC) Study in our prospective analysis. We used food frequency questionnaire responses to calculate four dietary scores: Healthy Eating Index-2015 (HEI2015), Alternative Healthy Eating Index-2010 (AHEI-2010), alternate Mediterranean (aMed) diet, and Dietary Approaches to Stop Hypertension (DASH). Participants were followed until the end of 2017 for incident dementia. Cox regression models adjusted for covariates were used to estimate risk of incident dementia by quintile of dietary scores. Results: Over a median of 27 years, there were 2,352 cases of incident dementia documented. Compared with participants in quintile 1 of HEI-2015, participants in quintile 5 (healthiest) had a 14% lower risk of incident dementia (hazard ratio, HR: 0.86, 95% confidence interval, CI: 0.74-0.99). There were no significant associations of incident dementia with the AHEI-2010, aMed, or DASH scores. There were no significant interactions by sex, age, race, education, physical activity, hypertension, or obesity. Conclusion: Adherence to the HEI-2015, but not the other dietary scores, during midlife was associated with lower risk of incident dementia. Further research is needed to elucidate whether timing of a healthy diet may influence dementia risk.
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