期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 44, 页码 12400-12412出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c05798
关键词
short-clustered maltodextrin; diabetes management; blood dyslipidemia; glucagon-like peptide 1; Akkermansia; butyrate
资金
- National Natural Science Foundation of China [31722040, 31771935]
- National First-Class Discipline Program of Food Science and Technology [JUFSTR20180204]
- Jiangsu province Collaborative Innovation Center of Food Safety and Quality Control industry development program
Molecular structure of starch in daily diet is closely associated with diabetes management. By enzymatically reassembling alpha-1,4 and alpha-1,6 glycosidic bonds in starch molecules, we have synthesized an innovative short-clustered maltodextrin (SCMD) which slowly releases glucose during digestion. Here, we investigated the potential benefits of the SCMD-containing diet using diabetic db/db mice. As compared to a diet with normal starch, this dietary style greatly attenuated hyperglycemia and repaired symptoms associated with diabetes. Additionally, in comparison with acarbose (an alpha-glucosidase inhibitor) administration, the SCMD-containing diet more effectively accelerated brown adipose activation and improved energy metabolism of db/db mice. Furthermore, the SCMD-containing diet was a more suitable approach to improving the intestinal microflora than acarbose administration, especially the proliferation of Mucispirillum, Akkermansia, and Bifidobacterium. These results reveal a novel strategy for diabetes management based on enzymatically rebuilding starch molecules in the daily diet.
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