期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 37, 页码 10015-10028出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c01968
关键词
tea polysaccharides; type 2 diabetes; hypoglycemic; hypolipidemic; gut microbiota; metabolism
资金
- National Natural Science Foundation of China for Distinguished Young Scholars [31825020]
- Program for National Key R&D Program of China [2017YFD0400203]
- Project of Academic Leaders of the Major Disciplines in Jiangxi Province [20162BCB22008]
- Outstanding Science and Technology Innovation Team Project in Jiangxi Province [20165BCB19001]
- Graduate Student Innovation Special Fund Support in Jiangxi Province [YC2018-S004]
- Collaborative Project in Agriculture and Food Field between China and Canada [2017ZJGH0102001]
Diabetes mellitus is a serious threat to human health. Tea is cultivated around the world, and its polysaccharide components are reported to be an effective approach for managing type 2 diabetes with fewer adverse effects than medication. To examine the therapeutic effect of tea polysaccharides on diabetes, a type 2 diabetic rat model was generated. We showed that tea polysaccharides remarkably decreased fasting blood glucose and the levels of total cholesterol, total triglyceride, low-density lipoprotein cholesterol, and free fatty acid of type 2 diabetic rats. 16S rRNA sequencing and metabolomics were used to investigate the variation of gut microbiota and the metabolites profiles of diabetic rats after intervention of tea polysaccharides. We found that tea polysaccharides maintained the diversity of gut microbiota and restored the relative abundance of some bacterial genera (Lachnospira, Victivallis, Roseburia, and Fluviicola) which was reduced by diabetes. According to metabolomics analysis, we found that amino acid and other related metabolites was influenced by tea polysaccharides intervention. Correlation analysis among metabolites, gut microbiota, and parameters of hypoglycemic indicated that tea polysaccharides had hypoglycemic and hypolipidemic effect on type 2 diabetes via the modulation of gut microbiota and the improvement of host metabolism.
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