期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 279, 期 -, 页码 343-352出版社
ELSEVIER
DOI: 10.1016/j.jad.2020.10.032
关键词
Major depressive disorder; Cognitive impairment; Years of schooling; Health-related variables; Physical activity; Age of onset
资金
- Carlos III Health Institute through the Ministry of Science, Innovation and Universities [PI15/00662, PI15/0039, PI15/00204]
- European Regional Development Fund (ERDF) A way to build Europe
- CIBERSAM
- Catalan Agency for the Management of University and Research Grants (AGAUR) [2017 SGR 1247]
- Miguel Servet II from the Carlos III Health Institute through the Spanish Ministry of Health [CP16/00020]
- FPI predoctoral grant from Universidad Autonoma de Madrid
The study found that patients with MDD have cognitive deficits compared to healthy controls, and these deficits are significantly associated with years of education, job status, age of onset of the disease, and physical activity.
Background. Cognitive impairment has been reported in patients with Major Depressive Disorder (MDD). This study aims to explore the association between lifestyle habits and health-related factors and the presence of cognitive symptoms in MDD patients. Methods. Demographic, clinical, health-related variables and cognitive scores measured with the Cambridge Neuropsychological Test Automated Battery (CANTAB) were compared between 74 patients with current MDD and 68 healthy controls (HC). To test the hypothesis of associated factors to cognitive symptoms, multivariate backward stepwise linear regression models were run. Results. Significant neuropsychological deficits were evident in MDD compared with HC in the global cognitive index (F=8.29; df=1, 140; p=0.005). In the regression analysis performed on MDD and HC, years of schooling (beta=-0.11; p=<0.001), job status (beta=-0.50; p=0.016), physical activity (beta=-0.25; p=0.04) and age at illness onset (beta=0.17; p=0.017) were statistically significant factors associated to cognitive impairment. The regression model ran in HC showed that only years of schooling were significant (beta=-0.07; p=<0.001) in this group. Limitations. Sample size was relatively small. Everyday cognitive skills were not evaluated. Conclusions. MDD patients have cognitive deficits. These deficits are linked with the years of education, job status, age of onset of the disease and the performance of physical activity. These results support the importance of the implementation of interventions targeting the cognitive reserve and lifestyle habits of MDD patients, in addition to the conventional therapeutic approach focused on symptoms control.
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