4.4 Article

Bone changes in early inflammatory arthritis assessed with High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT): A 12-month cohort study

期刊

JOINT BONE SPINE
卷 88, 期 1, 页码 -

出版社

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.jbspin.2020.07.014

关键词

Early inflammatory arthritis; Rheumatoid arthritis; High resolution peripheral quantitative computed tomography (HR-pQCT); Bone erosions; Bone mineral density

资金

  1. University of Calgary Research Grants Committee
  2. Natural Sciences and Engineering Research Council of Canada
  3. Arthritis Society (Canada) [STAR 18-0189]

向作者/读者索取更多资源

HR-pQCT is sensitive in detecting bone surface changes in early inflammatory arthritis (EIA) patients. Gradual degradation of joint space width proportional to symptom duration was observed in the study. Patients with EIA need close monitoring for exacerbation of arthritis and progression of periarticular bone damage.
Objectives: Erosion development is of crucial significance as it impacts prognosis and therapy decisions inpatients with inflammatory joint diseases. Our study aimed to determine the sensitivity of high-resolution peripheral quantitative computed tomography (HR-pQCT) to detect change of bone surface over time and to identify erosion development in early inflammatory arthritis (EIA) patients. Moreover, the contribution of prognostic factors on periarticular bone damage in the first year of diagnosis assessed by HR-pQCT was explored. Methods: 46 patients with arthritic symptoms for less than one year, and a clinical diagnosis of inflammatory arthritis were prospectively imaged at baseline and 12-months. HR-pQCT scans of the 2nd and 3rd MCP joints and CR of the hands and feet were performed. Joint space width (JSW), total bone mineral density (Tt.BMD), erosion presence and volume were assessed with HR-pQCT. Scan-rescan precision was assessed to define an individual-level least significant change (LSC) criterion. Regression analyses explored prognostic factors for bone damage progression. Results: We observed no significant group-level changes in JSW, Tt.BMD or erosion volume. 20% or fewer joints demonstrated individual-level changes greater than the LSC criterion for mean JSW, Tt.BMD and erosion volume. HR-pQCT detected more erosions than CR in the 2nd and 3rd MCP. Increased symptom duration at diagnosis was weakly associated (P < 0.10) with lower JSW minimum and higher JSW standard deviation. Conclusions: Gradual degradation of JSW, proportional to symptom duration, was detected by HR-pQCT. EIA patients need to be closely monitored for exacerbation of arthritis and progression of periarticular bone damage. (C) 2020 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据