期刊
INTERNATIONAL UROLOGY AND NEPHROLOGY
卷 53, 期 1, 页码 13-20出版社
SPRINGER
DOI: 10.1007/s11255-020-02627-3
关键词
Oxalobacter formigenes; Calcium oxalate urolithiasis; Bone mineral density; Testosterone; Colon cancer
The study found that kidney stone patients had lower colonization of O. formigenes, reduced bone mineral density, low testosterone levels, higher urinary calcium and oxalate levels, and decreased serum testosterone and urinary citrate concentrations. Additionally, there was an association between O. formigenes and colon cancer.
This is the first prospective study to investigate the association between kidney stones, bone mineral density, serum testosterone, colon cancer andO. formigenescolonization. 40 kidney stone patients and 85 controls were enrolled.O. formigenescolonization was established. BMD was examined from T- and Z-scores using dual energy absorptiometry.O. formigeneswas found in 28 of 40 cases and 80 of 85 controls. BMD was significantly reduced in patients (p < 0.05). The evaluation revealed a significant association between loweredO. formigenescolonization and low testosterone. Urinary calcium and oxalates levels were greater in patient. Serum testosterone and urinary citrate concentrations was reduced in patients with a significant difference. Also an association betweenO. formigenesand colon cancer was noted. Absence ofO. formigenesmight stand for a pathogenic factor in calcium oxalate stone, low bone mineral density, low testosterone levels and also colon cancer, when antibiotics are prescribed generously.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据