期刊
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
卷 109, 期 1, 页码 145-150出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2020.08.054
关键词
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资金
- Swedish Cancer Society [2016/510]
- Swedish Research Council [2015-02625, 2015-06268, 2017-05814]
- National Natural Science Foundation of China [81360405]
- Guangxi (China) Science and Technology Program Project [GK AD17129013]
- Natural Science Foundation of Guangxi Medical University [GXMUYSF201203]
- China Scholarship Council [201408450018]
- Swedish Research Council [2015-06268, 2015-02625, 2017-05814] Funding Source: Swedish Research Council
This study investigated the changes in the nasopharyngeal microbiome among patients with nasopharyngeal carcinoma during radiation therapy and found stable temporal changes. It provided preliminary evidence of an association between the microbiome changes and short-term clinical outcomes.
Purpose: The human commensal microbiome has been suggested to be involved in the regulation of response to anticancer therapies. However, little is known regarding changes in commensal microbes in patients with cancer during radiation therapy. We conducted a prospective, longitudinal proof-of-concept cohort study with patients with newly diagnosed nasopharyngeal carcinoma (NPC) who underwent radiation therapy-based treatment. Methods and Materials: Nasopharyngeal swabs were collected before radiation therapy, twice per week during radiation therapy, and after radiation therapy. The nasopharyngeal microbiome was assessed using 16S rRNA amplicon sequencing. A patient's response to treatment was measured 3 months after the completion of radiation therapy as a short-term clinical outcome. In total, 39 NPC patients with 445 nasopharyngeal samples were analyzed. Results: There was stable temporal change in the community structure of the nasopharyngeal microbiome among patients with NPC during treatment (P = .0005). Among 73 abundant amplicon sequence variants (ASVs), 7 ASVs assigned to genus Corynebacterium decreased significantly during the treatment (W-statistic >80%); 23 ASVs showed statistically significant changes in the ratio of abundance between early and late responders during treatment (false discovery rate <0.05). Conclusions: This study addressed stable temporal change in the nasopharyngeal microbiome among patients with NPC during radiation therapy-based treatment and provided preliminary evidence of an association with a short-term clinical outcome. (C) 2020 Elsevier Inc. All rights reserved.
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