期刊
CONNECTIVE TISSUE RESEARCH
卷 58, 期 6, 页码 497-508出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03008207.2016.1240790
关键词
Autophagy; articular cartilage; apoptosis; cell survival; osteoarthritis
资金
- National Research Foundation (NRF) - Korean government [2015R1A2A1A09002793]
- National Research Foundation of Korea [2015R1A2A1A09002793] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Osteoarthritis is characterized by continuous degeneration of articular cartilage resulting in disability. The death of chondrocytes and the loss of the extracellular matrix are the central peculiarities in cartilage degeneration during osteoarthritis pathogenesis. Autophagy is an essential cellular homeostasis mechanism whereby cellular organelles and macromolecules are recycled to maintain cellular metabolism. Autophagy is reported to be cytoprotective effects for articular cartilage, and osteoarthritis is associated with decreased autophagy. While autophagy is known to be cytoprotective to chondrocytes, its role may vary with differing stages and models of osteoarthritis. Therefore, more in-depth studies on autophagy are needed to determine its impact on cell survival and death in articular cartilage under various in vitro and in vivo conditions. Application of autophagy on osteoarthritis therapeutics will be possible after a profound understanding is established on the role of autophagy in osteoarthritis pathogenesis.
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