期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 588, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.119691
关键词
pH-responsive; Miniemulsion polymerization; ATRP; Hydrogels; Nanoparticles; Drug delivery
资金
- National Science Foundation [1033746]
- National Institutes of Health [R01-EB022025, R01-EB-00246-21]
- Cockrell Family Regents Chair Foundation
- Office of the Dean of the Cockrell School of Engineering at the University of Texas at Austin (UT)
- Institute for Biomaterials, Drug Delivery, and Regenerative Medicine
- National Science Foundation Graduate Research Fellowship Program [DGE-1610403]
Cationic polymers have garnered significant interest for their utility in intracellular drug delivery and gene therapy. However, due to their associated toxicities, novel synthesis approaches must be explored to develop materials that are biocompatible. The novel library of nanoparticles synthesized in this study exhibit tunable hydrodynamic diameters, composition and pH-responsive properties as a function of synthesis parameters. In addition, differences in the responsiveness of these nanoparticles under different pH conditions affords greater control over intracellular drug release.
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