期刊
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
卷 31, 期 2, 页码 238-246出版社
WILEY
DOI: 10.1111/ipd.12718
关键词
chemotherapy; methotrexate; oral mucositis; oral toxicity; paediatric oncology
资金
- PRONON/Ministry of Health, Brazil [25000.056.976/2015-52]
- Postgraduate Research Group of Porto Alegre Clinics Hospital [GPPG/FIPE: 2016-0608]
- Brazilian National Council for Scientific and Technological Development (CNPq)
- Children's Cancer Institute
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil(CAPES) [001]
This study evaluated the relationship between OM and MTX metabolism time and other toxicities in childhood cancer patients receiving HD-MTX. The results showed that OM is a prevalent complication in these patients, and renal and hepatic toxicity could be considered risk factors for OM, especially in patients with lymphoma.
Background Oral mucositis (OM) is one of the main adverse effects of the chemotherapeutic agent methotrexate (MTX). Aim To evaluate the relationship of OM with MTX metabolism time and other toxicities in childhood, cancer patients receiving high-dose of methotrexate (HD-MTX). Design Seventy-seven childhood patients receiving HD-MTX for treatment of leukaemia, osteosarcoma or lymphoma were evaluated. MTX serum level,hepaticand renal function parameters, and presence and intensity of OM were analysed. Results The patients were submitted to 255 cycles of chemotherapy. OM was diagnosed in 191 (74.9%) cycles. Of these, 119 (46.6%) presented ulcerative lesions. Lymphoma was associated with severe OM (P = .01). OM was associated with higher serum levels of aspartate aminotransferase (P = .006), alanine aminotransferase (P = .04) and creatinine (P = .008). Increase of one unit of total bilirubin and indirect bilirubin associated, respectively, with 11% and 39% higher prevalence of OM. For each increase of one unit of creatinine serum level, it was observed a 37% higher prevalence of OM in patients with lymphoma. No association was found between delayed excretion of MTX and OM development. Conclusions OM is a prevalent complication of childhood cancer patients receiving HD-MTX. Renal and hepatic toxicity could be considered risk factors for OM, especially in patients with lymphoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据