期刊
INTERNATIONAL JOURNAL OF NEUROSCIENCE
卷 132, 期 2, 页码 165-170出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207454.2020.1806265
关键词
Parkinson's disease; striatal asymmetry index; positron emission tomography; Hoehn & Yahr stage; posterior putamen
The study revealed a significant difference in SAI of the posterior putamen among different stages of PD severity. However, there was no significant difference in SAI of the anterior putamen or caudate nucleus. The SAI of the posterior putamen in PD patients was significantly higher compared to patients with other degenerative diseases.
Purpose Striatal asymmetry is a common feature in Parkinson's disease (PD), which changes with the progression of the disease. However, the correlation between the striatal asymmetry and severity of PD remains unclear. The present study aimed to investigate the characteristics of asymmetry in PD, and analyze the correlation between the striatal asymmetry index (SAI) and disease severity. Materials and methods This retrospective study enrolled 63 patients with idiopathic PD. The severity of PD was classified according to the Hoehn & Yahr (H&Y) staging system. The SAI in the subregions of the striatum was measured using(11)C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane (C-11-CFT) positron emission tomography (PET). Results There was a significant difference in the SAI of the posterior putamen among the three groups (H&Y stage I, H&Y stage II, and H&Y stage III-IV; p = 0.001). However, there was no difference in the SAI of the anterior putamen (p = 0.340) or SAI of the caudate nucleus (p = 0.342) among the three groups. The SAI of the posterior putamen in patients with PD was significantly higher than that in patients with multiple system atrophy or progressive supranuclear palsy (p = 0.008). Conclusion The SAI of the posterior putamen is associated with the severity of PD, and may be correlated to the loss of dopamine cells in the pars compacta of the ventrolateral substantia nigra projecting to the posterior putamen. The SAI may be a potential indicator for evaluating the severity of PD, and distinguishing PD from other degenerative diseases.
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