期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/ijms21207688
关键词
extracellular vesicles; cancer; therapeutic agents; cell-to-cell communication
资金
- H2020-MSCA-RISE-2018 [824036/2019]
- project PNCDI III 2015-2020 [29PFE/18.10.2018]
- Competitiveness Operational Program, 2014-2020 [35/01.09.2016, MySMIS 103375]
Communications among cells can be achieved either via direct interactions or via secretion of soluble factors. The emergence of extracellular vesicles (EVs) as entities that play key roles in cell-to-cell communication offer opportunities in exploring their features for use in therapeutics; i.e., management and treatment of various pathologies, such as those used for cancer. The potential use of EVs as therapeutic agents is attributed not only for their cell membrane-bound components, but also for their cargos, mostly bioactive molecules, wherein the former regulate interactions with a recipient cell while the latter trigger cellular functions/molecular mechanisms of a recipient cell. In this article, we highlight the involvement of EVs in hallmarks of a cancer cell, particularly focusing on those molecular processes that are influenced by EV cargos. Moreover, we explored the roles of RNA species and proteins carried by EVs in eliciting drug resistance phenotypes. Interestingly, engineered EVs have been investigated and proposed as therapeutic agents in various in vivo and in vitro studies, as well as in several clinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据