期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/ijms21165929
关键词
pain; transient receptor potential; TRP channel; taste; genomics; capsaicin
资金
- National Institute of Nursing Research [1ZIANR000035-01]
- Office of Workforce Diversity
- National Institutes of Health Distinguished Scholars Award
- Rockefeller University Heilbrunn Nurse Scholar Award
- Administrative Supplement on the NIH/NIMHD grant [R01MD010441-]
- UAB Faculty Development Award
- National Institute on Aging [T32AG049673]
- National Heart Lung & Blood Institute [1K01HL153210-01]
- Intramural Research Training Award, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services
- NATIONAL INSTITUTE OF NURSING RESEARCH [ZIANR000035] Funding Source: NIH RePORTER
Transient receptor potential (TRP) channels are a superfamily of cation transmembrane proteins that are expressed in many tissues and respond to many sensory stimuli. TRP channels play a role in sensory signaling for taste, thermosensation, mechanosensation, and nociception. Activation of TRP channels (e.g., TRPM5) in taste receptors by food/chemicals (e.g., capsaicin) is essential in the acquisition of nutrients, which fuel metabolism, growth, and development. Pain signals from these nociceptors are essential for harm avoidance. Dysfunctional TRP channels have been associated with neuropathic pain, inflammation, and reduced ability to detect taste stimuli. Humans have long recognized the relationship between taste and pain. However, the mechanisms and relationship among these taste-pain sensorial experiences are not fully understood. This article provides a narrative review of literature examining the role of TRP channels on taste and pain perception. Genomic variability in theTRPV1gene has been associated with alterations in various pain conditions. Moreover, polymorphisms of theTRPV1gene have been associated with alterations in salty taste sensitivity and salt preference. Studies of genetic variations inTRPgenes or modulation of TRP pathways may increase our understanding of the shared biological mediators of pain and taste, leading to therapeutic interventions to treat many diseases.
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