4.7 Review

Redox Regulation of STAT1 and STAT3 Signaling

期刊

出版社

MDPI
DOI: 10.3390/ijms21197034

关键词

STAT1; STAT3; oxidative stress; post-translational modifications

资金

  1. University of Verona, Italy
  2. Aboca, Sansepolcro (AR) Italy
  3. Italian Ministry for Research and Education [FUR2018MS]

向作者/读者索取更多资源

STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes. Despite being activated downstream of common cytokine and growth factors, STAT1 and STAT3 play essentially antagonistic roles and the disruption of their balance directs cells from survival to apoptotic cell death or from inflammatory to anti-inflammatory responses. Different mechanisms are proposed to explain this yin-yang relationship. Considering the redox aspect of STATs proteins, this review attempts to summarize the current knowledge of redox regulation of STAT1 and STAT3 signaling focusing the attention on the post-translational modifications that affect their activity.

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