期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/ijms21176248
关键词
single-cell mechanical model; micropipette aspiration; microfluidic; optical tweezers; atomic force microscope; disease diagnosis; regeneration and repair of biological tissue; micromanipulation
资金
- National Key R&D Program of China [2018YFB1304905]
- Natural Science Foundation of Jiangsu Province of China [BK20171215]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [17KJA460008]
Since the cell was discovered by humans, it has been an important research subject for researchers. The mechanical response of cells to external stimuli and the biomechanical response inside cells are of great significance for maintaining the life activities of cells. These biomechanical behaviors have wide applications in the fields of disease research and micromanipulation. In order to study the mechanical behavior of single cells, various cell mechanics models have been proposed. In addition, the measurement technologies of single cells have been greatly developed. These models, combined with experimental techniques, can effectively explain the biomechanical behavior and reaction mechanism of cells. In this review, we first introduce the basic concept and biomechanical background of cells, then summarize the research progress of internal force models and experimental techniques in the field of cell mechanics and discuss the latest mechanical models and experimental methods. We summarize the application directions of cell mechanics and put forward the future perspectives of a cell mechanics model.
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