期刊
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
卷 46, 期 5, 页码 1611-1632出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2020.4731
关键词
circular RNAs; miRNA sponges; gastrointestinal cancer; regulation; biomarkers
资金
- National Natural Science Foundation of China [81760550, 81460462]
- Postgraduate Innovation Fund Project of Nanchang University [X2019168]
Circular RNAs (circRNAs) are a type of endogenous non-coding RNAs that are connected at the 3' and 5' ends by exon or intron cyclization, which forms a covalently closed loop. They are stable, well conserved, exhibit specific expression in mammalian cells and can function as microRNA (miRNA or miR) sponges to regulate the target genes of miRNAs, which influences biological processes. Such as tumor proliferation, invasion, metastasis, apoptosis and tumor stage. circRNAs represent promising candidates for clinical diagnosis and treatment. In the present review, the biogenesis, classification and functions of circRNAs in tumors are briefly summarized and discussed. In addition, the participation of circRNAs in signal transduction pathways regulating gastrointestinal cancer cellular functions is highlighted.
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