期刊
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
卷 43, 期 2, 页码 329-335出版社
WILEY
DOI: 10.1111/ijlh.13374
关键词
COVID-19; disease severity; neutrophil-to-lymphocyte ratio
类别
资金
- National Natural Science Foundation of China [81801984, 81830003]
- National Key Research and Development Program of China [2019YFC130030]
- China Postdoctoral Science Foundation [2019M664008]
- Military Medical Science and Technology Youth Cultivation Project [20QNPY092]
Neutrophil-to-lymphocyte ratio is identified as a critical predictor for assessing disease severity in patients with COVID-19, showing close correlations with various laboratory indicators related to disease conditions.
Introduction Monitoring of laboratory indicators is important for predicting changes in disease severity and clinical outcomes. We aimed to identify the critical predictors that can effectively assess the disease conditions of patients with COVID-19 by analyzing the clinical characteristics and laboratory findings of patients with SARS-CoV-2 infection. Methods All consecutive patients (n = 294) with confirmed SARS-CoV-2 infection admitted to the General Hospital of Central Theater Command of the PLA from February 6 to February 21, 2020, were enrolled. These patients were divided into the severe group and the nonsevere group according to disease severity during hospitalization. Results The median neutrophil-to-lymphocyte ratio (NLR) value of the severe patients was dramatically higher than that of the nonsevere patients (10.4 vs 2.6; P < .001). The NLR value equal to 5 was a boundary value worthy of reference, because more than 80% severe patients had an NLR value greater than 5 and over 80% nonsevere patients had an NLR value less than 5. The NLR value of these COVID-19 patients was positively and respectively correlated with the values of C-reactive protein (R = .5921, P < .001), lactate dehydrogenase (R = .4509, P < .001), procalcitonin (R = .5504, P < .001), fibrinogen (R = .4710, P < .001), and D-dimers (R = .4425, P < .001). However, the NLR value was merely and positively correlated with the interleukin-6 value (R = .3594, P < .05), but had no correlations with the values of interleukin-10, interleukin-4, interleukin-17, interferon-gamma, and tumor necrosis factor-alpha (P > .05). Discussion Neutrophil-to-lymphocyte ratio is a critical predictor for assessment of disease severity in patients with COVID-19, and it has a close relation with the laboratory indicators related to disease conditions.
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