期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 102, 期 -, 页码 10-13出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2020.10.040
关键词
SARS-CoV-2; Other respiratory viruses; Co-infection; Lower respiratory tract
The study found that during the early outbreak of COVID-19, there were co-infections of SARS-CoV-2 with other respiratory viruses in patients, and lower respiratory tract samples could improve the accuracy of diagnosing COVID-19.
Objectives: This study was performed during the early outbreak period of coronavirus disease 2019 (COVID-19) and the seasonal epidemics of other respiratory viral infections, in order to describe the extent of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with other respiratory viruses. It also compared the diagnostic performances of upper respiratory tract (URT) and lower respiratory tract (LRT) samples for SARS-CoV-2 infection. Methods: From 25 January to 29 March 2020, all URT and LRT samples collected from patients with suspected COVID-19 received in the virology laboratory of Pitie-Salpetriere University Hospital (Paris, France) were simultaneously tested for SARS-CoV-2 and other respiratory viruses. Results: A total of 1423 consecutive patients were tested: 677 (47.6%) males, 746 (52.4%) females, median age 50 (range, 1-103) years. Twenty-one (1.5%) patients were positive for both SARS-CoV-2 and other respiratory viruses. The detection rate of SARS-CoV-2 was significantly higher in LRT than in URT (53.6% vs. 13.4%; p < 0.0001). The analysis of paired samples from 117 (8.2%) patients showed that SARS-CoV-2 load was lower in URT than in LRT samples in 65% of cases. Conclusion: The detection of other respiratory viruses in patients during this epidemic period could not rule out SARS-CoV-2 co-infection. Furthermore, LRT samples increased the accuracy of diagnosis of COVID-19. (C) 2020 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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