期刊
INTERNATIONAL JOURNAL OF CANCER
卷 148, 期 4, 页码 876-883出版社
WILEY
DOI: 10.1002/ijc.33267
关键词
biomarkers; nested case-control study; prostate cancer; selenium; single nucleotide polymorphisms
类别
资金
- Danish Cancer Society
- Deutsche Forschungsgemeinschaft [849/6-1]
- Health Research Board of Ireland [HRA_PHS/2015/1142]
- Wereld Kanker Onderzoek Fonds as part of the World Cancer Research Fund International [2015/1412]
The study did not find any association between toenail selenium or plasma SELENOP concentrations with advanced, high-grade or advanced-stage prostate cancer. Additionally, variations in selenoprotein genes were not found to be associated with PC risk.
Low selenium status may be associated with increased risk of prostate cancer (PC), particularly aggressive PC, and variation in selenoprotein genes may constitute an important modifying factor. We aimed to investigate the association between two selenium status biomarkers [toenail selenium, plasma selenoprotein P (SELENOP)] and risk of advanced, high-grade and advanced-stage PC. We further studied whether variations in selenoprotein genes were associated with PC risk and selenium biomarker concentrations. In the Diet, Cancer and Health cohort, 27 178 men aged 50 to 65 years were enrolled from 1993 to 1997. Between baseline and 2012, 1160 cohort participants were diagnosed with advanced PC; among these 462 had high-grade and 281 had advanced-stage disease at diagnosis. Each case was risk set-matched to one control. Toenail selenium and plasma SELENOP concentrations were measured by neutron activation analysis and a SELENOP-ELISA, respectively, and genotyping was performed for 27 selected single nucleotide polymorphisms (SNPs) in 12 selenium pathway genes (including seven selenoproteins) by allele-specific PCR. Toenail selenium and circulating SELENOP concentrations were not associated with advanced, high-grade or advanced-stage PC. After adjustment for multiple testing, none of the genes were associated with PC risk. Neither toenail selenium nor plasma SELENOP was associated with advanced, high-grade or advanced-stage PC.
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