Kaolinite/cashew gum bionanocomposite for doxazosin incorporation and its release

Incorporation of drugs in day minerals has been widely proposed for the controlled-release or increased solubility of drugs. In this context, a bionanocomposite based on kaolinite and cashew gum (KM/Gum) was synthesized and characterized by X-ray diffraction (XRD), thermal analysis (TG/DTA), and Fourier transform infrared spectroscopy (FTIR). The bionanocomposite was applied to the incorporation and further release of doxazosin mesylate (DB). The influence of solution pH (1-3), adsorbent dose (20-50 mg), initial drug concentration (20.0 70.0 mg L-1), contact time (15-300 min), and temperature (25, 35, and 45 degrees C) were systematically evaluated. Equilibrium was reached around 60 min, with a maximum adsorption capacity of 31.5 = 2.0 mg g(-1) at a pH of 3.0 and 25 degrees C. Hydrogen bonding contributed to DB incorporation on the Kin/Gum. In addition, DB maximum amounts of 16.80 = 0.58 and 77.00 +/- 2.46% were released at pH values of 1.2 and 7.4, respectively. These results indicated that the KIn/Gum bionanocomposite is an effective and promising material for the incorporation/release of drugs with similar structures to DB. (C) 2020 Elsevier B.V.Published by Elsevier B.V.