期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 158, 期 -, 页码 662-669出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.04.192
关键词
Fucoidan; Sodium alginate; Lead; Oxidative stress; Rats
资金
- China Agricultural Research System [CARS-50]
- Central Public-interest Scientific Institution Basal Research Fund, YSFRI, CAFS [20603022018017]
- Central Publicinterest Scientific Institution Basal Research Fund, CAFS [2020TD71]
The current study was performed to evaluate the possible protective effects of fucoidan (F) and sodium alginate (SA) against lead-induced oxidative damage in vivo, and to identify relevant underlying mechanisms. Health Sprague Dawley (SD) rats were divided into nine groups of ten rats each and treated orally with lead acetate (5 mg/kg, Pb2+) for 4 weeks, then gavaged with DMSA (Meso-2, 3-dimercaptosuccinic acid, 25 mg/kg), F (50, 100, 200 mg/kg) and SA (50, 100, 200 mg/kg) individually after successful modelling. We found that the admin-istration of both F or SA resulted in a beneficial effect by significantly decreasing lead levels (p < 0.05) in the kid-neys from 2.85 mg/kg to 0.79 mg/kg and improving antioxidant status (SOD, GSH, and CAT) thereby alleviating lead-induced damage and injury of the liver and kidneys (AST, BUN, and Cr). Both natural extracts exerted dose -dependent effects. Protective effects were further demonstrated by histopathology. Our results demonstrate that the F and SA are effective natural extracts for lead-eliminating, and that they can ameliorate oxidative damage induced by lead toxicity. (C) 2020 Elsevier B.V. All rights reserved.
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