期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 159, 期 -, 页码 859-869出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.05.145
关键词
Carrageenan; Lignin; Silver nanoparticles; Nanocomposite hydrogels; Antibacterial activity; Wound dressing
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2019R1A2C2084221]
Carrageenan-based functional wound dressing materials were prepared through a one-pot green synthesis of silver nanoparticles (AgNPs) using lignin as a reducing and capping agent in the carrageenan matrix cross-linked with divalent cations such as CaCl2, CuCl2, and MgCl2. The wound healing efficacy of the hydrogel film was evaluated using Sprague-Dawley rats. Crosslinking with divalent cations improved the physical properties of carrageenan-based hydrogels containing AgNPs such as strength, flexibility, swelling ratio, and release rate of Ag ions depending on the type of crosslinking agent used. The carrageenan-based hydrogels were biocompatible against the mouse fibroblast cell line (L929 cell line). Carra/Lig/AgNPs/MgCl2 hydrogel significantly healed the wounds in Sprague-Dawley rats within two weeks, reducing the wound area to b3%, which was further confirmed by histological analysis with the epidermis and mature glands. Carrageenan-based multifunctional hydrogels have a high potential for wound dressing applications. (C) 2020 Elsevier B.V. All rights reserved.
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