期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 126, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2020.105818
关键词
Airway smooth muscle; Asthma; Bronchial thermoplasty; Pharmacological therapy
资金
- Thoracic Society of Australia and New Zealand/National Asthma Council of Australia -Asthma and Airways Career Development Fellowship
- National Health and Medical Research Council (NHMRC) [1090888]
- Royal Society of New Zealand, Marsden Fund [14-UOA-145]
- Western Australian Department of Health
- Medical and Health Research Infrastructure Fund
- NHMRC Ideas Grant [1180854]
- National Health and Medical Research Council of Australia [1180854] Funding Source: NHMRC
Asthma: A disease characterised by excessive and variable airway narrowing, and pathologies of inflammation and remodelling, particularly thickening of the airway smooth muscle (ASM). Treatment approaches dilate narrowed airways and reduce inflammation; however, remodelling seems largely neglected. This review considers the evolution of remodelling in asthma and whether conventional hypotheses that inflammation causes ASM thickening has mislead the medical community into thinking that anti-inflammatories will remedy this ASM defect. There is instead reasonable evidence that ASM thickening occurs independently of inflammation, such that therapies should employ strategies to directly modify ASM growth. Lessons have been learned from the use of untargeted bronchial thermoplasty and there should also be consideration of pharmacological therapies to ablate ASM. We discuss several new approaches to target ASM remodelling in asthma. A major current obstacle is our inability to image the ASM layer and assess treatment response. In this regard, polarisation-sensitive optical coherence tomography offers future promise.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据