期刊
INTERNATIONAL ENDODONTIC JOURNAL
卷 54, 期 1, 页码 85-99出版社
WILEY
DOI: 10.1111/iej.13400
关键词
dental nerve; immune system; inflammation; peripheral nerve; pulpitis
资金
- Natural Science Foundation of China [81500870, 81971902]
- Student's Platform for Innovation and Entrepreneurship Training Program [c1051222]
Dental nerves play crucial roles in tooth pain induction, sensitization, and maintenance, as well as regulating non-neuronal cells and immune responses. They are also involved in the repair of dental soft and hard tissues, highlighting their importance in pulpitis and potential implications for endodontic treatment.
As one of the most densely innervated tissues, the dental pulp contains abundant nerve fibres, including sensory, sympathetic and parasympathetic nerve fibres. Studies in animal models and human patients with pulpitis have revealed distinct alterations in protein expression and histological appearance in all types of dental nerve fibres. Various molecules secreted by neurons, such as classical neurotransmitters, neuropeptides and amino acids, not only contribute to the induction, sensitization and maintenance of tooth pain, but also regulate non-neuronal cells, including fibroblasts, odontoblasts, immune cells and vascular endothelial cells. Dental nerves are particularly important for the microcirculatory and immune responses in pulpitis via their release of a variety of functional substances. Further, nerve fibres are found to be involved in dental soft and hard tissue repair. Thus, understanding how dental nerves participate in pulpitis could have important clinical ramifications for endodontic treatment. In this review, the roles of dental nerves in regulating pulpal inflammatory processes are highlighted and their implications for future research on this topic are discussed.
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