Di(hydroperoxy)cycloalkane Adducts of Triarylphosphine Oxides: A Comprehensive Study Including Solid-State Structures and Association in Solution

Four new di(hydroperoxy)cycloalkane adducts (Ahn adducts) of p-Tol(3)PO (1) and o-Tol3PO (2), namely, p-Tol3PO.(HOO)(2)C(CH2)(5) (3), o-Tol(3)PO.(HOO)2C(CH2)5 (4), p-Tol3PO.(HOO)2C(CH2)6 (5), and o-Tol3PO.(HOO)(2)C(CH2)(6) (6), have been synthesized and fully characterized. Their single crystal X-ray structures have been determined and analyzed. The P NMR data are in accordance with hydrogen bonding of the di(hydroperoxy)alkanes to the P-O groups of the phosphine oxides. Due to their high solubility in organic solvents, natural abundance 17O NMR spectra of 16 could be recorded, providing the signals for the P-O groups and additionally the two different oxygen nuclei in the OOH groups in the adducts 36. The association and mobility of 36 were explored by 1H DOSY (diffusion ordered spectroscopy) NMR, which indicated persistent hydrogen bonding of the adducts in solution. Competition experiments with phosphine oxides allowed ranking of the affinities of the di(hydroperoxy)cycloalkanes for the different phosphine oxide carriers. On the basis of variable temperature 31P NMR investigations, the Gibbs energies of activation Delta G double dagger for the adduct dissociation processes of 36 at different temperatures, as well as the enthalpy Delta H double dagger and entropy ?S double dagger of activation, have been determined. IR spectroscopy of 36 corroborated the hydrogen bonding, and in the Raman spectra, the Delta(OO) stretching bands have been identified, confirming the presence of peroxy groups in the solid materials. The high solubilities in selected organic solvents have been quantified.