期刊
IMMUNOLOGICAL INVESTIGATIONS
卷 51, 期 2, 页码 266-289出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08820139.2020.1828453
关键词
Autophagy; apoptosis; cellular immune disorder; infectious diseases; cancer therapy
类别
资金
- Egyptian Science and Technology Development Fund (STDF) [6117, 4694]
Autophagy is a cellular process that maintains cell survival and energy sources, and is associated with the development of many human diseases. Controlling autophagy levels can effectively combat these diseases and the ongoing coronavirus epidemic.
Autophagy is a cellular housekeeping process that incorporates lysosomal-degradation to maintain cell survival and energy sources. In recent decades, the role of autophagy has implicated in the initiation and development of many diseases that affect humanity. Among these diseases are autoimmune diseases and neurodegenerative diseases, which connected with the lacking autophagy. Other diseases are connected with the increasing levels of autophagy such as cancers and infectious diseases. Therefore, controlling autophagy with sufficient regulators could represent an effective strategy to overcome such diseases. Interestingly, targeting autophagy can also provide a sufficient method to combat the current epidemic caused by the ongoing coronavirus. In this review, we aim to highlight the physiological function of the autophagic process to understand the circumstances surrounding its role in the cellular immunity associated with the development of human diseases.
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