期刊
IEEE TRANSACTIONS ON NANOBIOSCIENCE
卷 19, 期 4, 页码 627-632出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2020.3007103
关键词
Peptides; Nanoparticles; Microfluidics; Nanobioscience; Hydrodynamics; Solvents; Ethanol; Self-assembling peptides; theranostic nanoparticles; microfluidics
资金
- Centre National de la Recherche Scientifique (CNRS), France, through the Projet de cooperation Impression - CoopIntEer (PICS) Program [6662]
- Project NUCLEU IMT MICRO-NANO-SYS under Grant +2020
- Institute of Bioengineering and Nanotechnology (IBN)
- Agency for Science, Technology and Research (A*Star)
Ultrashort peptides (USPs), composed of three to seven amino acids, can self-assemble into nanofibers in pure water. Here, using hydrodynamic focusing and a solvent exchange method on a microfluidic setup, we convert these nanofibers into globular nanoparticles with excellent dimensional control and polydispersity. Thanks to USP nanocarriers' structure, different drugs can be loaded. We used Curcumin as a model drug to evaluate the performance of USP nanocarriers as a novel drug delivery vehicle. These nanoparticles can efficiently cross the cell membrane and possess nonlinear optical properties. Therefore, we envisage USP nanoparticles as promising future theranostic nanocarriers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据