期刊
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
卷 39, 期 10, 页码 2489-2502出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TCAD.2019.2940688
关键词
Valves; Biochips; Switches; Multiplexing; Logic design; Fault tolerance; Channel multiplexing; control logic; fault tolerance; flow-based microfluidic biochips
类别
资金
- Deutsche Forschungsgemeinschaft through the TUM International Graduate School of Science and Engineering
- Technical University of Munich -Institute for Advanced Study - German Excellence Initiative
- European Union [291763]
Flow-based microfluidic biochips are one of the most promising platforms used in biochemical and pharmaceutical laboratories due to their high efficiency and low costs. Inside such a chip, fluids of nanoliter volumes are transported between devices for various operations, such as mixing and detection. The transportation channels and corresponding operation devices are controlled by microvalves driven by external pressure sources. Since assigning an independent pressure source to every microvalve would be impractical due to high costs and limited system dimensions, states of microvalves are switched by a control logic using time multiplexing. Existing control-logic designs, however, still switch only a single control channel per operation, leading to a low efficiency. In this article, we present the first automatic synthesis approach for a control logic that is able to switch multiple control channels simultaneously. Moreover, we propose the first fault-aware design in control logic by introducing backup control paths to maintain the correct function even when manufacturing defects occur. The construction of control logic is achieved by a highly efficient framework based on particle swarm optimization, Boolean logic simplification, grid routing, together with mixing multiplexing. The simulation results demonstrate that the proposed multichannel switching mechanism leads to fewer valve-switching times and lower total logic cost, while realizing fault tolerance for all control channels.
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