期刊
HUMAN BRAIN MAPPING
卷 42, 期 1, 页码 36-46出版社
WILEY
DOI: 10.1002/hbm.25201
关键词
alcohol addiction; dorsolateral prefrontal cortex; dynamic functional connectivity; functional magnetic resonance imaging; striatum
资金
- Bundesministerium fur Bildung und Forschung [01GQ1003B, 01ZX1311A]
- Deutsche Forschungsgemeinschaft [402170461 - TRR 265, SFB 636/D6]
- Horizon 2020 Framework Programme [668863]
This study developed a circuit-specific fMRI analysis approach to detect dynamic changes in frontostriatal functional connectivity in AUD patients. The results consistently showed a ventral shift in right orbitofrontal cortex PeaCoG in AUD patients, and reduced temporospatial variability of dynamic PeaCoG in the left dorsolateral prefrontal cortex was associated with self-efficacy and days of abstinence.
Alcohol use disorder (AUD) is associated with changes in frontostriatal connectivity, but functional magnetic resonance imaging (fMRI) functional connectivity (FC) approaches are usually not adapted to these circuits. We developed a circuit-specific fMRI analysis approach to detect dynamic changes in frontostriatal FC inspired by medial-ventral-rostral to lateral-dorsal-caudal frontostriatal gradients originally identified in nonhuman primate tract-tracing data. In our PeaCoG (peakconnectivity on agradient) approach we use information about the location of strongest FC on empirical frontostriatal connectivity gradients. We have recently described a basic PeaCoG version with conventional FC, and now developed a dynamic PeaCoG approach with sliding-window FC. In resting state data ofn= 66 AUD participants andn= 40 healthy controls we continue here the analyses that we began with the basic version. Our former result of an AUD-associated ventral shift in right orbitofrontal cortex PeaCoG is consistently detected in the dynamic approach. Temporospatial variability of dynamic PeaCoG in the left dorsolateral prefrontal cortex is reduced in AUD and associated with self-efficacy to abstain and days of abstinence. Our method has the potential to provide insight into the dynamics of frontostriatal circuits, which has so far been relatively unexplored, and into their role in mental disorders and normal cognition.
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