Molecular pathogenesis and prognostication of low-grade'' and high-grade endometrial stromal sarcoma

Endometrial stromal sarcomas (ESS) are a heterogeneous group of rare mesenchymal cancers. Considerable knowledge has been gained in recent years about the molecular characteristics of these cancers, which helps to classify them in a more meaningful manner leading to improved diagnosis, prognostication, and treatment. According to this classification, ESS is now grouped as low- or high-grade. ESS may have overlapping clinical presentation, morphology, and immunohistochemical profile. Their genetic characteristics allow subdivision of many of them depending on which pathogenetically important fusion genes they carry, but clearly much more needs to be unraveled in this regard. We here provide an overview of the molecular pathogenetic knowledge gained so far on low- and high-grade ESS.

Automated summary

Endometrial stromal sarcomas (ESS) are a rare and heterogeneous group of mesenchymal cancers, now classified as low- or high-grade. They may have overlapping clinical presentation, morphology, and immunohistochemical profile. Understanding the molecular characteristics of ESS can improve diagnosis, prognostication, and treatment.