期刊
GASTROENTEROLOGY
卷 160, 期 4, 页码 1384-1393出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2020.08.063
关键词
Immune Checkpoint Inhibitor; Toxicity; Adverse Event; Enterocolitis; Hepatitis
资金
- National Institutes of Health Mentored Clinical Scientist Development Award [1K08DK114563-01]
- American Gastroenterological Association Research Scholars Award
Immune checkpoint inhibitors have revolutionized oncology treatment but come with potentially life-threatening toxicities, particularly affecting the gastrointestinal tract and liver. This review combines expert clinical opinion with comprehensive literature search to provide best practice advice for diagnosis and management.
BACKGROUND & AIMS: Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for oncology, leading to durable remissions in a subset of patients, but also a broad range of potentially life-threatening inflammatory toxicities, many of which involve the gastrointestinal (GI) tract and liver. The purpose of this expert review was to update gastroenterologists on the gastrointestinal and hepatic toxicities of ICIs and provide best practice advice on their diagnosis and management. METHODS: The evidence reviewed in this work combines the expert clinical opinion of the authors with a comprehensive search of several English-language databases and a manual review of relevant publications.
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