期刊
FUTURE ONCOLOGY
卷 17, 期 8, 页码 869-876出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2020-0621
关键词
cytotoxic chemotherapy; gastric cancer; immune checkpoint inhibitor; nivolumab
类别
Nivolumab is increasingly utilized in Japan as a standard care treatment for heavily pretreated patients with advanced gastric cancer. Retrospective studies have shown potential improvement in objective response rate to cytotoxic chemotherapy after exposure to immune checkpoint inhibitors. The multicenter observational REVIVE study aims to evaluate the efficacy and safety of cytotoxic chemotherapy in nivolumab-refractory or nivolumab-intolerant patients with advanced gastric cancer.
Nivolumab is an increasingly used standard care treatment for heavily pretreated patients with advanced gastric cancer, with increasing clinical use in Japan. Data from retrospective studies on various tumors have shown the objective response rate to cytotoxic chemotherapy potentially improves after an exposure to immune checkpoint inhibitors. Based on these data, we conducted the multicenter observational REVIVE study to evaluate the efficacy and safety of cytotoxic chemotherapy in nivolumab-refractory or nivolumab-intolerant patients with advanced gastric cancer. Patients who are refractory or intolerant to nivolumab and scheduled to receive irinotecan monotherapy, oxaliplatin combination treatment or oral trifluridine/tipiracil hydrochloride therapy will be included. The primary end point is overall survival of nivolumab-pretreated patients with advanced gastric cancer after the cytotoxic chemotherapy. Lay abstract Nivolumab is an increasingly used standard care treatment for heavily-pretreated patients with advanced gastric cancer, with increasing clinical use in Japan. Data from retrospective studies on various tumors have shown the objective response rate to cytotoxic chemotherapy potentially improves after an exposure to immune checkpoint inhibitors. Based on these data, we conducted the multicenter observational REVIVE study to evaluate the efficacy and safety of cytotoxic chemotherapy in nivolumab-refractory or nivolumab-intolerant patients with advanced gastric cancer.
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