期刊
FOOD RESEARCH INTERNATIONAL
卷 136, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.foodres.2020.109510
关键词
Inulin; Antioxidant; Hepatoprotection; Baccharis trimera; Asteraceae
资金
- Brazilian agency CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [404717/2016-0, 307977/2015-3, 305787/2018-7, 310332/20150]
- Brazilian agency CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) [001]
Baccharis trimera is a native medicinal plant from South America popularly known as carqueja. Its infusion is traditionally ingested for the treatment and prevention of hepatic disorders. Up to now, only the crude aqueous extract or hydroethanolic fractions, containing the secondary metabolites, have been studied and correlated with their biological action on the liver. Here we report that an inulin type fructan is present in the B. trimera infusion and contributes to the hepatoprotective effect of the species. In vitro, inulin at 300 mu g/mL, was able to scavenger 97% of the DPPH radicals. In vivo experiments showed that it protected the liver against CCl4 -induced injuries. The administration of inulin at low dose of 1 mg/kg significantly reduced the blood levels of ALT, AST and ALP, reduced the lipid peroxidation and increased the catalase activity and the levels of reduced glutathione in the liver of CCl4-treated mice. Moreover, the administration of inulin at 100 mg/kg increased GSH levels in the liver of Naive mice. No signs of toxicity were observed. Thus, inulin present in B. trimera infusion protects the liver from the oxidative stress caused by CCl4 administration and can corroborate with the hepatoprotective effects presented by the species infusion.
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