4.7 Article

Improvement in host metabolic homeostasis and alteration in gut microbiota in mice on the high-fat diet: A comparison of calcium supplements

期刊

FOOD RESEARCH INTERNATIONAL
卷 136, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.foodres.2020.109495

关键词

Calcium carbonate; Calcium citrate; Gut microbiota; Metabolic homeostasis; In vivo mice experiment

资金

  1. Bio & Medical Technology Development Program of the National Research Foundation - Ministry of Science ICT [NRF-2016M3A9D3915857]
  2. Korea Institute of Science and Technology [2Z06220]
  3. National Research Foundation of Korea [2016M3A9D3915857] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Despite the previously reported health benefits of calcium intake for the attenuation of metabolic disease, few studies have investigated the relationships among calcium intake, gut microbiota, and host metabolism. In this study, we assessed the effects of calcium supplementation on host microbial community composition and metabolic homeostasis. Mice were fed a high-fat diet with different calcium concentrations (4 and 12 g/kg) of 2 calcium supplements, calcium carbonate and calcium citrate. Supplementation with the higher concentration of calcium citrate significantly prevented body weight gain and decreased plasma biomarkers for metabolic disorder compared to calcium carbonate supplementation. Both calcium supplementation led to changes in microbial composition, increased propionate production and increased anorexigenic GLP-1 gene expression. The calcium citrate groups also experienced less metabolic endotoxemia. Our findings suggested that calcium supplementation could ameliorate host metabolic disorder caused by a high-fat diet, due to gut microbiota changes as well as decreased intestinal inflammation.

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