期刊
FOOD CHEMISTRY
卷 343, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2020.128395
关键词
Gut microbiota; High fat diet; Obesity; Polysaccharide; Raphanus sativus
资金
- Main Research Program of the Korea Food Research Institute (KFRI) - Ministry of Science and ICT
In high fat diet-induced obese mice, the polysaccharide fraction of radish greens showed anti-obesity activity by reducing weight gain and body fat percentage. This effect was achieved through improving gut barrier function, modulating gut microbiota, and regulating lipid metabolism.
Radish (Raphanus sativus) greens are commonly used as a vegetable in Korea; however, their anti-obesity effect has not been reported yet. We prepared the polysaccharide fraction of radish greens (PRG) and assessed its anti obesity activity in high fat diet (HFD)-induced obese C57BL/6J mice. Supplementation with 4 mg/kg PRG reduced weight gain and body fat percentage, and regulated serum biomarkers against HFD-induced obesity. Moreover, PRG treatment improved gut permeability by increasing tight junction protein expression and colon length shortening. HFD intake increased the proportion of Firmicutes and decreased the proportion of Bacteroidetes and Verrucomicrobia; however, PRG supplementation maintained gut microbial composition to normal diet condition. Moreover, PRG reduced HFD-induced increase of lipid metabolism-related protein expression, along with adipocyte size in white adipose tissue. These results indicated that PRG as a potential prebiotic, has anti-obesity properties by improving gut barrier function, modulating gut microbiota and regulating lipid metabolism.
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